The basic premise of the game is that the player characters are Garou, or werewolves, who have undergone some training and succeeded in a rite of passage. After this, they advance in rank by working together to gain fame.

The Garou battle to maintain this world before all the negativity leads to a total collapse, the titular "apocalypse". They hide it from the public eye and live in secret from humanity in general. In their war, the Garou often hunt down and kill humans and supernatural creatures that either actively pursue the apocalypse or unwittingly contribute to it, due to their parasitic nature. This includes fallen Garou, vampires, evil spirits, mages, and humans (and other creatures) possessed by demons. In doing so, the Garou regard themselves as the immune system of the planet.